Miguel Díaz-Canel addressed crowds in Havana the US is attempting to destroy Cuba’s political system.
He said the US seeks complete control over the island.
Díaz-Canel called US policies a form of political genocide during July 26 events.
He warned this is a menace to the country's sovereignty.
Raúl Castro was absent from the largest rally.
Tensions stay high because of sanctions and US political pressure.